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Vetdle Archive

Archive Case #133: Canine Pemphigus Foliaceus

Dog veterinary case - Hard - July 14, 2026

Clinical Clues

  1. A dog is evaluated for a spreading crusting skin problem.
  2. The lesions affect the face, ear pinnae, and areas around the eyes.
  3. The owner says the problem began as pustules that quickly crusted.
  4. Footpads are sore and hyperkeratotic.
  5. Cytology and biopsy support an autoimmune superficial pustular dermatitis.
  6. Canine pemphigus foliaceus causes superficial pustules and crusting, often involving the face and footpads.

Diagnosis

Canine Pemphigus Foliaceus

This case is most consistent with Canine Pemphigus Foliaceus because the dog has pustules, facial crusting, footpad involvement, and biopsy evidence of autoimmune skin disease. The most important clues are the lesion distribution and superficial pustular pattern, which make bacterial folliculitis less likely.

Learning review

Review the case evidence

Use the paired clues to explain how the evidence in this dog case supports the provided diagnosis, Canine Pemphigus Foliaceus, then compare your reasoning with the case explanation.

Evidence checkpoints

Clues 1-2

  1. Clue 1: A dog is evaluated for a spreading crusting skin problem.
  2. Clue 2: The lesions affect the face, ear pinnae, and areas around the eyes.

Clues 3-4

  1. Clue 3: The owner says the problem began as pustules that quickly crusted.
  2. Clue 4: Footpads are sore and hyperkeratotic.

Clues 5-6

  1. Clue 5: Cytology and biopsy support an autoimmune superficial pustular dermatitis.
  2. Clue 6: Canine pemphigus foliaceus causes superficial pustules and crusting, often involving the face and footpads.

Self-review prompts

  1. After clues 1-2, what evidence from this dog case shaped your initial interpretation?
  2. When you compare clues 3-4 with clues 1-2, what changed in your reasoning about Canine Pemphigus Foliaceus?
  3. How do clues 5-6 align with the case explanation for Canine Pemphigus Foliaceus?

Educational Use

Vetdle archive cases are educational veterinary games for diagnostic reasoning practice. They do not provide veterinary advice, diagnosis, treatment, or professional medical guidance.